Can I use an Eagle chain with the XPLR derailleur and cassette? August 09, 2021 21:43 Updated No. The XPLR derailleurs and 12-speed cassettes are compatible with Flattop 12-speed chains only. Related articles Can I use an Eagle derailleur with the 12-speed 10-44T cassette? What Eagle AXS components are compatible with SRAM XPLR eTap AXS? Can I use my existing eTap AXS 1x crankset with the XPLR rear derailleur and 10-44T cassette? Can I use an Eagle chain with the XPLR direct mount chainring? What chain should I use with the XPLR rear derailleur and cassette? Comments 0 comments Article is closed for comments.