Yes, provided you have a rear wheel with an XDR driver body. Replacement XDR driver bodies are available from most wheel manufacturers to retrofit 11-speed road rear wheels, or if you currently have 8-speed, 9-speed, or 10-speed drivetrain you are replacing, upgrading your wheelset to one that incorporates a rear wheel with an XDR driver body will allow you to install the groupset on your bike.
For more information on 11 speed eTap compatibility with AXS components, check out our FAQs on AXS compatiblilty with 11 speed eTap.