Yes, in the following manner:
- eTap AXS™ shifters
- Eagle™ cassette
- Eagle™ chain
- Eagle™ or eTap AXS™ crank
SRAM RED and Force eTap AXS™ chains are only compatible with SRAM RED and Force eTap AXS™ chainrings. Eagle™ chains are designed only for 1x drivetrains with a 10-50 or 11-50 Eagle™ cassette (note: SRAM RED and Force eTap AXS™ 12-speed chains are designed only to be used with RED and Force eTap AXS™ 12-speed XDR cassettes).