Can I configure eTap AXS™ for a lower 1x drivetrain gearing setup?

Yes, in the following manner:

1. eTap AXS™ shifters
2. Eagle™ cassette
3. Eagle™ chain
4. Eagle™ or eTap AXS™ crank

SRAM RED and Force eTap AXS™ chains are only compatible with SRAM RED and Force eTap AXS™ chainrings. Eagle™ chains are designed only for 1x drivetrains with a 10-50 or 11-50 Eagle™ cassette (note: SRAM RED and Force eTap AXS™ 12-speed chains are designed only to be used with RED and Force eTap AXS™ 12-speed XDR cassettes).