Can I run a SRAM Road Flattop chain on my SRAM Eagle drivetrain? No. Our Flattop chains are designed for 12-speed AXS road use only. Always make sure that the chain is compatible with your cassette and rear derailleur. If you are not sure about compatibility, we have you covered with our compatibility chart. Related articles Can I use an Eagle chain with the XPLR direct mount chainring? Why do the new SRAM RED and Force eTap AXS road chains have links that are flat on one side? Are SRAM RED and Force eTap AXS PowerLocks different from SRAM Eagle 12-speed PowerLocks? Are SRAM GX Eagle PowerLocks compatible with SRAM eTap AXS 12-speed PowerLocks? What is the difference between SRAM Eagle and XPLR drivetrains?